Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease

, … Based Study Consortium, Alzheimer's Disease … - Molecular …, 2021 - nature.com
… We now report a large genome-wide association meta-analysis of 12,317 AD subjects with
and without psychosis. We identified two loci with genome-wide significant associations with …

[HTML][HTML] Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease

, … consortium and the Alzheimer's Disease … - Translational …, 2019 - nature.com
… Linkage studies have also implicated regions of the … study which, surprisingly, reported that
a genetic risk score comprising 94 SNPs reaching genome-wide significance for association

Genetic risk for schizophrenia and psychosis in Alzheimer disease

MAA DeMichele-Sweet, EA Weamer, L Klei… - Molecular …, 2018 - nature.com
… recently reported the first genome-wide association study (GWAS) of AD… genome-wide
significance, likely because of modest sample size, there was suggestive evidence for association

Genetics of psychosis of Alzheimer disease

C Shah, MAA DeMichele‐Sweet… - American Journal of …, 2017 - Wiley Online Library
… Other candidate gene studies focusing on monoamine … A genome-wide association study
and studies examining copy number variations recently have detected suggestive associations

Genomewide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways

…, Alzheimer's Disease Genetics Consortium… - Alzheimer's & …, 2020 - Wiley Online Library
… exists in the disease trajectories of Alzheimer's disease (AD) patients. We performed a
genome-wide association study to examine rate of cognitive decline (ROD) in patients with AD. …

[HTML][HTML] Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank

C Gouveia, E Gibbons, N Dehghani, J Eapen… - Scientific Reports, 2022 - nature.com
genome-wide association studies (GWAS) have greatly improved the statistical power to detect
novel genetic associations … can be observed with psychiatric traits such as schizophrenia, …

[HTML][HTML] Assessing the presence of shared genetic architecture between Alzheimer's disease and major depressive disorder using genome-wide association data

J Gibson, TC Russ, MJ Adams, TK Clarke… - Translational …, 2017 - nature.com
… score regression with genome-wide association study (GWAS… of Alzheimer's Project (IGAP)
and the Psychiatric Genomics … with Alzheimer's disease. Nat Genet 2009; 41: 1094–1099. …

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease

DP Wightman, IE Jansen, JE Savage, AA Shadrin… - Nature …, 2021 - nature.com
… not found to be genome-wide significant in this study, five of those were just below
significance and two were driven by rare variants (largely) not included in this study (Supplementary …

Association between schizophrenia polygenic score and psychotic symptoms in Alzheimer's disease: meta-analysis of 11 cohort studies

, … consortium and the Alzheimer's Disease … - BioRxiv, 2019 - biorxiv.org
… Linkage studies have also implicated regions of the genome in AD… study which reported
that a genetic risk score comprising 94 SNPs reaching genome wide significance for association

Five major psychiatric disorders and Alzheimer's disease: a Bidirectional Mendelian Randomization Study

T Wei, Z Guo, Z Wang, C Li, W Zhu… - … of Alzheimer's …, 2022 - content.iospress.com
… potential causality between five psychiatric disorders and AD by selecting the single-nucleotide
polymorphisms from the genome-wide association studies as instrumental variables. …